# Sine circadian model

[Generated automatically as a Generation summary]

## Inputs

### Description

Name: | circ_sin
Title: | Sine circadian model
Author: | Wright Dose Ltd
Abstract: |

A PD Model based on the amount of drug in the body.
The PD model uses a sine function which simulates a circadian rhythm for the generation of a biomarker.
The amount in the central compartment is determined by CL and V, PK patameters , which have been previosly estimated for each individual.
The amount in the central compartment influences the rate of production of a biomarker.

Keywords: | PD; Pharmacodynamics; sine function; Circadian rhythm
Input Script: | `circ_sin_gen.pyml`
Diagram: |

### True f[X] values

    f[AMP] = 2.0000
    f[INT] = 8.0000
    f[KOUT] = 0.0500
    f[ANOISE] = 3.0000

## Outputs

### Generated parameter .csv files

Fixed Effects: | `fx_params.csv (gen)`
Random Effects: | `rx_params.csv (gen)`
Model params: | `mx_params.csv (gen)`
State values: | `sx_params.csv (gen)`
Predictions: | `px_params.csv (gen)`
Synthetic Data: | `synthetic_data.csv (gen)`

## Plots

### Dense sim plots

Alternatively see All dense_sim graph plots