:orphan: 





.. _direct_pd_fit:



Direct PD Model
###############

[Generated automatically as a Fitting summary]

Inputs
******



Description
===========

:Name: direct_pd

:Title: Direct PD Model

:Author: Wright Dose Ltd

:Abstract: 

| A simple direct PD Model, based on the amount of drug in the body.
| The amount in the central compartment is determined by K, which has been previously estimated for each individual.
| The amount in the central compartment influences the rate of removal of a biomarker (KOUT).

:Keywords: pd; one compartment model; direct

:Input Script: :download:`direct_pd_fit.pyml <direct_pd_fit.pyml>`

:Input Data: :download:`synthetic_data.csv <synthetic_data.csv>`

:Diagram: 


.. thumbnail:: direct_pd_fit.pyml_output/fit/compartment_diagram.svg
    :width: 200px


Initial fixed effect estimates
==============================

.. code-block:: pyml

    f[BASE] = 500.0000
    f[KOUT] = 0.1000
    f[ANOISE] = 5.0000



Outputs
*******



Final objective value
=====================

.. code-block:: pyml

    460.7314


which required 1.16 iterations and took 1.47 seconds

Final fitted fixed effects
==========================

.. code-block:: pyml

    f[BASE] = 800.0443
    f[KOUT] = 0.0300
    f[ANOISE] = 10.0000



Fitted parameter .csv files
===========================


:Fixed Effects: :download:`fx_params.csv (fit) <direct_pd_fit.pyml_output/fit/solN/fx_params.csv>`

:Random Effects: :download:`rx_params.csv (fit) <direct_pd_fit.pyml_output/fit/solN/rx_params.csv>`

:Model params: :download:`mx_params.csv (fit) <direct_pd_fit.pyml_output/fit/solN/mx_params.csv>`

:State values: :download:`sx_params.csv (fit) <direct_pd_fit.pyml_output/fit/solN/sx_params.csv>`

:Predictions: :download:`px_params.csv (fit) <direct_pd_fit.pyml_output/fit/solN/px_params.csv>`



Plots
*****



Dense sim plots
===============



.. thumbnail:: images/fit_dense/000001.svg
    :width: 200px


Alternatively see :ref:`direct_pd_dense_sim_plots`

Comparison
**********



Compare Main f[X]
=================


===============  ================  ==============  =============  ============
Variable Name      Starting Value    Fitted Value    Prop Change    Abs Change
===============  ================  ==============  =============  ============
f[BASE]                  500.0000        800.0443         0.6001      300.0443
f[KOUT]                    0.1000          0.0300         0.6999        0.0700
===============  ================  ==============  =============  ============

Compare Noise f[X]
==================


===============  ================  ==============  =============  ============
Variable Name      Starting Value    Fitted Value    Prop Change    Abs Change
===============  ================  ==============  =============  ============
f[ANOISE]                  5.0000         10.0000         1.0000        5.0000
===============  ================  ==============  =============  ============

Compare Variance f[X]
=====================


